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doi:10.5578/tt.3552
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Comparison of QuantiFERON-TB gold in-tube test with tuberculin skin test in children
who had no contact with active tuberculosis case

Özge METİN TİMUR1, Gönül TANIR1, Fatma Nur ÖZ1, Gülsüm İclal BAYHAN2, Türkan AYDIN TEKE3, Nilden TUYGUN2


1 Clinic of Infectious Diseases, Dr. Sami Ulus Maternity and Children Health and Diseases Training and Research Hospital,

Ankara, Turkey

2 Department of Children's Health and Diseases, Dr. Sami Ulus Maternity and Children Health and Diseases Training and

Research Hospital, Ankara, Turkey

3 Clinic of Pediatric Infectious Diseases, Dr. Sami Ulus Maternity and Children Health and Diseases Training and

Research Hospital, Ankara, Turkey

SUMMARY

Comparison of QuantiFERON-TB gold in-tube test with tuberculin skin test in children who had no contact with active tuberculosis case

Introduction: In this study, we aimed to compare QuantiFERON-TB gold in-tube test (QFT-GIT) and tuberculin skin test (TST) as a diagnosis of latent tuberculosis infection in the children with Bacille Calmette-Guerin (BCG) vaccine.

Materials and Methods: We evaluated 81 children in the study who have positive TST result without a known history of tuberculosis  contact from 2008 to 2011 prospectively. Patients were separated into groups according to their ages, the reason of TST application, number of BCG vaccination scars and diameter of TST induration. Posteroanterior, lateral chest radiographies and computerized tomography, if necessary, were performed.

Results: The study consists of 48 (59.3%) boys and 33 (40.7%) girls with a mean age of 94.8 ± 51.9 months (ranged from 6 to 193 months). Sixty nine (85.2%) children had one and 12 (14.8%) had two BCG vaccination scars. The TST induration diameters were 15-19 mm in 65 (80.2%) children and ≥ 20 mm in 16 (19.8%) children. QFT-GIT positivity was found in 12 (14.8%) of the evaluated patients. QFT-GIT positive patients were treated with triple anti-tuberculosis regime or isoniazid (INH). In three years period of study, there were no tuberculosis disease observed among the children who had not been treated with anti-tuberculosis drugs.

Conclusion: As a result of the study it is suggested to confirm positive TST results with tests based on interferon-gamma (IFN-γ) because it can reduce false positive diagnosis and treatment of latent tuberculosis infection, thus adverse reactions of drugs, in countries where BCG vaccination is routinely recommended especially for low risk children.

Key words: Latent tuberculosis infection, tuberculin skin test, QuantiFERON-TB gold in-tube test, Bacille Calmette-Guerin vaccine, interferon-γ

Address for Correspondence

Dr. Özge Metİn Tİmur

Dr. Sami Ulus Kadın Doğum,

Çocuk Sağlığı ve Hastalıkları Eğitim ve

Araştırma Hastanesi,

İnfeksiyon Hastalıkları Kliniği,

ANKARA - TURKEY

e-mail: drozgemetintimur@gmail.com

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