Cardiovascular biomarkers in clinical practice of sleep apnea
Dursun
DURSUNOĞLU1, Neşe DURSUNOĞLU2
1 Department of Cardiology, Faculty of Medicine, Pamukkale University, Denizli,
Turkey,
2 Department of Chest Diseases, Faculty of Medicine, Pamukkale University,
Denizli, Turkey.
SUMMARY
Obstructive
sleep apnea syndrome (OSAS) leads to cardiovascular complications such as
coronary artery disease, left/right ventricular hypertrophy and dysfunction,
heart failure, systemic and pulmonary hypertension, arrhythmias and stroke; and
these all cardiovascular complications increase morbidity and mortality of
OSAS. However, Cheyne-Stokes respiration, central and obstructive apneas may
occur in the patient with heart failure. Increased sympathetic activity by
hypoxemia and endotelial dysfunction play a role in cardiovascular
complications. Some cardiovascular biomarkers have a role in early diagnosis,
treatment and prognosis. In the present review, some cardiovascular biomarkers
such as serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α),
interleukins, adiponectin, heart-type fatty acid binding protein (hFABP) and
brain (B-type) natriuretic peptide (BNP), and their clinical importance were
reviewed.
Key
Words: Sleep apnea syndrome, cardiovascular biomarkers,
C-reactive protein, tumor necrosis factor-alpha, interleukins, adiponectin,
heart-type fatty acid binding protein, brain (B-type) natriuretic peptide.
Address for Correspondence:
Dr.
Dursun DURSUNOĞLU,
Pamukkale
Üniversitesi Tıp Fakültesi,
Kardiyoloji
Anabilim Dalı,
Kınıklı
Kampüsü 20200 DENİZLİ - TURKEY
e-mail:
dursundursunoglu@yahoo.com
