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doi:10.5578/tt.1448
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Uyku apnesinin klinik uygulamasında kardiyovasküler biyobelirteçler

Cardiovascular biomarkers in clinical practice of sleep apnea

Dursun DURSUNOĞLU1, Neşe DURSUNOĞLU2


1 Department of Cardiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey,

2 Department of Chest Diseases, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

SUMMARY

Obstructive sleep apnea syndrome (OSAS) leads to cardiovascular complications such as coronary artery disease, left/right ventricular hypertrophy and dysfunction, heart failure, systemic and pulmonary hypertension, arrhythmias and stroke; and these all cardiovascular complications increase morbidity and mortality of OSAS. However, Cheyne-Stokes respiration, central and obstructive apneas may occur in the patient with heart failure. Increased sympathetic activity by hypoxemia and endotelial dysfunction play a role in cardiovascular complications. Some cardiovascular biomarkers have a role in early diagnosis, treatment and prognosis. In the present review, some cardiovascular biomarkers such as serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukins, adiponectin, heart-type fatty acid binding protein (hFABP) and brain (B-type) natriuretic peptide (BNP), and their clinical importance were reviewed.

Key Words: Sleep apnea syndrome, cardiovascular biomarkers, C-reactive protein, tumor necrosis factor-alpha, interleukins, adiponectin, heart-type fatty acid binding protein, brain (B-type) natriuretic peptide.

Address for Correspondence:

Dr. Dursun DURSUNOĞLU,

Pamukkale Üniversitesi Tıp Fakültesi,

Kardiyoloji Anabilim Dalı,

Kınıklı Kampüsü 20200 DENİZLİ - TURKEY

e-mail: dursundursunoglu@yahoo.com

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